Every job and situation will be different. Having done a year of nocturnist work, I can tell you that 10 days straight would not be sustainable for me. We thinking coming from residency that 10-days straight is no big deal, but I promise you that you will burn out with that schedule. Do you really need 20 days off in a row? That is a lot.
Also, most gigs are not 5 on 10 off as your theoretical job is.