Hey all, Im doing an assignment for the treatment I would give the following patient; 58 year old woman, presents with nausea, headaches and short term memory loss. CT and MRI show multiple (5) intracranial lesions with vasogenic oedema and ring enhancement. She has no known primary so a CT TAP was done and a 5.1cm lesion in the rUL was noted with right mediastinal, hilar and supraclavicular lymphadenopathy. Biospy indicated NSCLC stage IV - squamous type. KPS of 80 so she would be RPA II, as the primary is not controlled? How would other people treat this patient? I have said because of the multiple lesions no surgery and because of high overall tumour volume no SRS. 16mg a day of Dexamethasone. She has no symptoms of her primary disease so I am unsure with regards to chemotherapy; should I give her chemo after her WBRT, or at all? if so, what agent should I use. As she is SCC it can be presumed that she is EGFR and ALK neg and so I have not mentioned Erlotinob... Am not using a radiosensitizer as I live in Ireland and its use is uncommon here.