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O-chem lab TLC Question

Discussion in 'Pre-Pharmacy' started by starrfishes, Dec 4, 2005.

  1. starrfishes

    starrfishes Member
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    This is a random o-chem lab question that I'm totally stuck with. :oops:

    So my question is, how do we know if our reaction ran to completion for monitoring a ketone reduction reaction of Fluorenone to Fluorenol, with TLC (thin-layer chromatography)?

    Do Rf factors help when the results show no big difference?

    Is there any visible evidence that indicated the reaction went to completion?


    Any help is greatly appreciated.
     
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  3. Requiem

    Requiem Senior Member
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    Well, upon TLC analysis did you have one, or two spots?

    One spot would indicate the prescence of 1 compound -> completion.
    2 spots -> 2 compounds -> Rx incomplete.

    There will be a difference in the Rf values between the spots because there will be a different polarity acheived, therefore a different distance travelled up the sheet.
     
  4. inocenciotj

    inocenciotj Junior Member
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    And, if I might add... if u needed to identify which was which, fluorenol should have the lower Rf, since it can hydrogen bond.
     
  5. starrfishes

    starrfishes Member
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    Good point! I just noticed, after hours of staring at the book that compounds with greater polarity have a lower Rf. Thank you for your response, inocenciotj!
     
  6. starrfishes

    starrfishes Member
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    You guys are the greatest, thank you so much for the responses!! :)
     

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