Oestrogen TYPE during menstrual cycle

[Phloston]

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After a drastic drop in oestrogen immediately following ovulation, it gradually increases between days 14 and 21 of the menstrual cycle as a result of augmented synthesis secondary to progesterone production. Is the major oestrogen type during this week estradiol, estrone or estriol, and why?

Please be specific. What is the mechanism?

 

[Belleza156]

Estradiol: Is the young female's hormone of femininity. It's also called E2. It's prododuced by aromatization of Testosterone in the Graafian follicle (granulosa cell). It's the most potent estrogen with the highest effect on receptors.

Estrone: Is the estrogen of the menopause. It's produced by aromatization of androstenedione in peripheral (fatty) tissue. It's also called E1. It's less potent than Estradiol.

Estriol: Is the placental estrogen and it's only seen during pregnancy and it's high levels reflects fetal well being. It's also called E3. It's the least potent of all estrogens. It originates from the fetal adrenal gland in the form of DHEA Sulfate and then is finally transformed to Estriol in the placenta by the sulfatase enzyme.

 

[Phloston]

Good point about estrone being the most common post-menopausal oestrogen, however I've also read that it's the major pre-menopausal oestrogen reservoir, because it's converted to a long-term storage form called estrone sulfate.

I still don't think I have an answer here. Estradiol is clearly granulosa-produced prior to ovulation, but the drop following is due to follicular rupture and disruption of the granulosa-driven production. The only thing I'm trying to get answered here is what type of oestrogen comes from progesterone synthesis, because it's progesterone functioning as an oestrogen precursor that drives the post-ovulatory oestrogen-rise.

 

[Belleza156]

I didn't know that about the largest reservoir being estrone sulfate......so far in all the UWorld questions I encountered where they test menstrual physiology, the estrogen they refer to is estradiol.

 

[Belleza156]

Maybe this shows what you are looking for? But what do you mean progesterone is the precursor for estrogen post ovulation?

 

[Boardz]

what type of oestrogen comes from progesterone synthesis, because it's progesterone functioning as an oestrogen precursor that drives the post-ovulatory oestrogen-rise.

Two types of estrogen comes from progesterone synthesis. Estrone and estradiol. If you want to know in what exact proportion comes from the progesterone exclusively coming from the ruptured follicle exactly in the time period of a week following ovulation...

please tell us when you find this information.