What's the one most trusted product/product combo you recommend? We are using Comfortis and Interceptor. I am open to any school of thought or opinions you have on this subject. Happy to hear your experiences too. I live in South Florida, so some type of protection is necessary, but I am hoping new advances will make for less adverse reactions or unknown variables in future products. I am not too comfortable with any of these preventatives, but we use them. Comfortis indicates two issues...serizures in dogs prone to neurological problems and phospholipidosis in ALL dogs aka vacuolation of lymphoid tissue (the severity of the latter is unknown and the cause of either is unknown), but hey, they have no problems making and selling it. Ya know, I am definitely not well versed here, but I have read that phospholipidosis occurring in hepatocytes, kidneys, and lungs, is insanely sereve and can cause failure of liver, kidney, and respiratory function. The phospholipidosis in Comfortis is stated to occur in lymph tissue and there is no further explaination of it. We'll see what a few more years in reasearch brings. Any experiences with Comfortis? Something you can shed light on? Is this a trusted product for you?