i'm actually sick of seeing multiple threads asking the same thing. for college seniors who have already gotten accepted into med school-- it's OK to get a C, not a D or F (in my school, F is a R). if you get a C, the school will ask for an explanation or an opporunity for you to explain. FEW schools are cool with a C, but they will tell you in the acceptance letter. for rising pre-meds: if you happen to get a C or B- or such in a pre-req, then you are OKAY if you can pull off an A in the 2nd part of the course. for example, you get a C in ochem I and you put off an A in ochem II. plus, you should not be worried about individual grades as much. you should worry about your overall BCPM. regardless of how many Cs you get, you need to somehow get at least around a 3.4 BCPM... 3.5 BCPM to be safe... even if you get Cs in prereqs, you better start taking some easy science courses to boost the BCPM. myth busted and case closed.