If an adult starts smoking at age 40 and develops emphysema and liver disturbances within 5 years, is he a PiMZ heterozygote or a PiZZ homozygtoe? His brother died at age 10 due to liver and lung failure.
Is the question trying to indicate that the brother had a full-blown PiZZ mutation and the adult has smth less severe, which only became evil once he started smoking, and which now of course wud mean a PiMZ heterozygote in this case?
Several sources say though that PiMZ carriers are largely asymptomatic and might at their worst get emphysema only, and not necessarily accompanying liver failure. This pt has both. So what do you think ?