Ofirmev for infants ?

[YGK]

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Do you give ofirmev IV for less than 2 year old ?

 

[deleted171991]

Do you give ofirmev IV for less than 2 year old ?

Pediatric Use: The effectiveness of OFIRMEV for the treatment of
acute pain and fever has not been studied in pediatric patients
less than 2 years of age. The safety and effectiveness of
OFIRMEV in pediatric patients older than 2 years is supported by
evidence from adequate and well controlled studies in adults with
additional safety and pharmacokinetic data for this age group.

 

[YGK]

I don't see why one wouldn't, as long as it's the right dose. I don't do pedi cases, I am just curious.

Ofirmev site dose recommendations > 2 years . However it doesnt say it's contraindicated, it says that efficacy is not tested .

 

[deleted171991]

Ofirmev site dose recommendations > 2 years . However it doesnt say it's contraindicated, it says that efficacy is not tested .

I corrected my post after I noticed that.

Interestingly their studies have included even neonates.

 

[WholeLottaGame7]

Do you give ofirmev IV for less than 2 year old ?

Yes. 7.5mg/kg for neonates, though. 10mg/kg from 1 month up til 6-9months, 15mg/kg after about 9 months.

 

[urge]

Yes. 7.5mg/kg for neonates, though. 10mg/kg from 1 month up til 6-9months, 15mg/kg after about 9 months.

What is the basis of this dosing?

 

[RockYourRonium]

And also used in place of ibuprofen or indomethacin for PDA closure. 15 mg/kg. http://www.ncbi.nlm.nih.gov/m/pubmed/25781500/


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[WholeLottaGame7]

What is the basis of this dosing?

Rough estimate of the timeline for hepatic maturity over the first year of life. I use similar dosing for PO formulations. Haven't given PR in 2 years of doing primarily peds.