Re: orgo. It is very essential in Med Chem and probably not as important as biochem in pharmacokinetics, but still necessary.
Re: PChem, I started P.Chem the week after my first child was born. It was a grueling two quarters. It's not that it was hard, just so many disciplines thrown in at once. My prof went to Indiana in the 50's and stressed knowing the derivations of the various PChem equations. The first quarter covered the finer details of G.Chem from a Physics standpoint, but required a background in Calculus more than physics or G.Chem. The second quarter was thermodynamics and was almost completely reaction rates using different variables (Pressure, Temperature, Ionic Strength, etc) If I could suggest anything before taking his PChem class it would be to review Calc I/II. I didn't necessarily need to know inorganic chemistry or physics (though it did help) but if you weren't rock solid on derivations (partial derivatives especially) it was hard to keep up. I ended up with a C the 1st quarter and a C+ the second. I'm sure not all PChem professors are like that, but hope it gives you an idea what some people get.