Paradoxical aciduria in vomiting.

[veganbythefjord]

1. In vomiting, there is intial loss of HCL so kidney tried to correct hypochloremia by throwing out Na& Hco3. But with continious vomiting and RAAS being turned on, Aldosterone reabsorbs Na via PCT NaKatpase and throws out pottasium. So to correct hypokalemia, theK/H transporter tries to conserve pottasium and throws out H so acidic urine. Am I correct in this?

2. Also I read that Aldosterone causes sodium reabsorption making the lumen negative so pottasium and H goes out to maintain neutrality.

I have been banging my head on the wall for the past couple of hours trying to figure this out, kindly help please. Thank you.

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[Gurby]

That logic seems reasonable to me.

This Zanki card seems to agree:

In a low K+ state, H+ is exchanged for Na+ in the basolateral membrane of cortical collecting tubule, causing alkalosis and "paradoxical aciduria"

normally K+ is exchanged for Na+; may occur with thiazide and loop diuretics