the reason i took time off was to build my application. penn kicked my butt as far as gpa goes, and i knew i was more than the numbers reflected on my transcript as I graduated. So i decided to take some time off and do some research to both gain additional experience (i had work study research jobs while in college) and just to make some cash before i go totally indebted in loans with med school. Also, because I work at Penn, I get to take classes for free here (tuition benefits) so I've been taking the post bac classes and doing pretty well in them, so I get both a post bac advantage of high level, med school like courses and got to boost my gpa up, which showed that I really could handle such course load and that I'm not the naive, unprepared kid I was 6 yrs ago, walking into Penn. Pretty much, any time off, voluntary or involuntary, use it to your benefit. Try to shadow, volunteer, take classes, research - do anything that might be lacking or might need strengthening in your application. Good luck with it all