- Joined
- Jul 29, 2007
- Messages
- 7,009
- Reaction score
- 4,494
Pertussis toxin is an ADP ribosylating A-B toxin with two components:
^ is this more or less accurate?
- A (Active) component ADP-ribosylates Gi by removing the ADP-ribosyl group from NAD and covalently attaching it to Gi which causes Gi inactivation and subsequently increased cAMP, increased secretion of Na+, Cl-, H2O from cells, edema, and neutrophil dysfunction.
- B (Binding) component facilitates endocytosis.
^ is this more or less accurate?