BMBiology pretty much hit every point, the only thing I would add is that as a PIC you now get to experience being hounded by your boss for flu shots, MTM, script sales, and other things. I went into pharmacy to make a decent salary, have a stable job, and little stress. I'd take a pretty decent pay cut to NOT be the PIC.
This depends highly on chain and store. PIC for Kroger or Safeway, easier than CVS by a long shot.
PIC of new store is gonna have it pretty tough to grow the business the way corporate wants .
New grad can't get PIC of elite store because those are cruise control positions where pic is making tons of money for very little work ... Ideally you would want a medium volume store with growth potential or a high volume turn around project , anything else and I would argue it's not worth the money. One new grad PIC in my district is busting his ass and failing to get his script count up ... If he can't hit his minimum target his store will be closed. It's not his fault, he just has a bad location. Also you never want to take over for a baller PIC because if you don't maintain those numbers, questions are going to be asked.
My advice would be , if you are truly insanely passionate about your company and retail pharmacy, and you aren't headed for a lose-lose situation, give it consideration. If you are just an average "awesome" staff Rph you need to decide if you want to dedicate a lot of your time and effort... The money would be easier to make just working OT.
If you have an aptitude for management and a good store opportunity and you know the corporate score , it can be a win win .. but you are gonna have a handful of big struggles no matter how plum your location is ... Whether it be clinical programs, Rph or tech staffing, volume, compliance, or budget cuts.. one of the above WILL happen, and if you aren't ready to be up at night thinking about solutions and giving(donating) your time to implement them, it isn't worth the money.
Also take a close look at your boss's track record .. is your store manager or DM a good guy who knows the score ? You will need to have each other's back when it comes to corporate , or it is all pointless in the end anyway . I am on the same page as my store manager and we run the pharmacy as a team even though he is technically my boss. From what I've heard this goes for CVS as well, if your DM is on your side, your life can be a lot easier than if they are just a corporate yes-man or chasing a promotion.