Physio Absorption Q (EK Lecture Q #14)

[qtsjoe]

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"Most of the glycogen in the human body is stored in the liver and the skeletal muscles. Which of the following hormones inhibits glycogenolysis?"

A. Cortisol
B. Insulin
C. Glucagon
D. Aldosterone

Cortisol and Glucagon increase blood glucose level. Insulin decreases blood glucose level. Aldosterone is an irrelevant hormone (Ions..water reabsorption).

Glycogenolysis produces glycogen from the liver which is similar to increasing blood glucose levels.

Exam Krackers says the answer is B. Insulin.

I am confused because hormones act in a way of negative feedback. Wouldn't glucagon or cortisol be the answers? Glucagon/Cortisol increases blood glucose levels, and the body would respond (If glucose is too high) by secreting insulin or decrease blood glucose. NOT decrease glucose by way of insulin.

I think insulin would stimulate glycogenolysis or produce more blood glucose levels because insulin decreases blood glucose...

 

[MT Headed]

Glucagon/Cortisol increases blood glucose levels,

Yes. By glycogenolysis. You're overthinking a really simple question.

 

[Essee]

You're definitely over thinking this.

Insulin is released when blood glucose is high, like after a meal. It would be pretty redundant for insulin to cause the release of glucose by glycogenolysis from the liver and then lower the blood glc levels by making cells uptake it, as you seem to be saying. Insulin does not create higher blood glucose levels, insulin responds to high blood glucose levels.

 

[Kimchii]

Glucagon is associated with glycogenolysis because it increases glucose levels in the blood. To inhibit this, do the opposite. The opposite effect of glucagon on the body is insulin.

 

[geeyouknit]

Glycogenolysis produces glycogen from the liver which is similar to increasing blood glucose levels.

Exam Krackers says the answer is B. Insulin.

I am confused because hormones act in a way of negative feedback. Wouldn't glucagon or cortisol be the answers? Glucagon/Cortisol increases blood glucose levels, and the body would respond (If glucose is too high) by secreting insulin or decrease blood glucose. NOT decrease glucose by way of insulin.

I think insulin would stimulate glycogenolysis or produce more blood glucose levels because insulin decreases blood glucose...

Glycogenolysis doesn't produce glycogen. It breaks down glycogen into glucose. Now it should make more sense? Insulin acts to keep glucose out of the glood, so it tries to create more glycogen and prevent glycogen breakdown (ie, lysis).

 

[tendiw]

Glycogenolysis doesn't produce glycogen. It breaks down glycogen into glucose. Now it should make more sense? Insulin acts to keep glucose out of the glood, so it tries to create more glycogen and prevent glycogen breakdown (ie, lysis).

Actually insulin promotes the uptake of glucose into cells thereby removing glucose from the blood. Insulin doesn't create glycogen. The cell itself when confronted with high amounts of glucose will make glycogen, liver will make glycogen too. The reason why it can be said that insulin is the correct answer and it inhibits glyconeogenesis it that is it antagonistic to the function of glucagon plus cortisol really and glucagon cannot function in the presence of insulin as a catabolic and anabolic reaction cannot directly compete like this in the body at the same time.

Gluconeogenesis is the production of glucose from NON-CARBOHYDRATE substances (like glycerol), which is what cortisol and glycogen do in order to increase blood glucose. Insulin is only the best choice as it works antagonistically with gluconeogenesis.

Gluconeogenesis, glycolysis, and glycogenolysis (breaking down of glycogen) are completely different processes and should not be mixed. Cortisol promotes gluconeogenesis.

Remeber-corstisol=gluconeogenesis
Gulcagon=gluconeogenesis and glycogenolysis
Insulin=opposes all of these

A good way to differentiate gluconeogenesis and glycogenolysis is this:

"Neo" means new so new carbon source other than carbohydrates and "genesis" means beginning or creation.

"lysis" means to break or burst (burst is used when virsus multiply and lyse or break out of host cell)

Finally glycogen is made by muscle and liver cell primarily

 

[geeyouknit]

Actually insulin promotes the uptake of glucose into cells thereby removing glucose from the blood. Insulin doesn't create glycogen.

Thanks for the clarification. My main point was that the reason the OP couldn't get the answer is because his definition of glycogenolysis was the opposite of what it really is.