As I finalize my first K08 application, I thought it might be nice to break up the hegemony of the usual "what are my chances" posts with some discussion about career choices and development. How many of you out there finishing or having finished your training not only wish to continue a research-oriented career, but also want to run your own labs and write grant applications for a living? What are the alternatives? Most of my peers, even those who are still committed to research, hope to do so now on a more limited basis- like 50% protected time with no space, but will be part of large collaborative projects or participate in clinical research. Thoughts?