I orient the bevel of the needle in the direction of the vein. Before threading the wire, I push a little bit of the wire out and verify which direction it will be curling. Then I rotate and thread the wire where the curl will be facing the direction of the vein where I want it to proceed. If I'm using the US, I then glance briefly at the major veins nearby to make sure it's not going in the wrong direction, otherwise I re-thread. With this technique, I can't remember the last time I had a wire go in the wrong direction. Keep in mind, my usual line is an infraclavicular subclavian and I prefer the R side which is an even more acute angle. You just have to be cognizant of the curl on the wire and making sure it's oriented in the direction that you want to line to progress. I sometimes forget to orient the bevel of the needle and as long as I'm focused on the wire, it still always threads in the right direction.