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15+ Year Member
Jan 15, 2004
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Hi guys,
I'm the process of writing up an essay on biology of aggression in children/adolescents. I need two specific bits of information:

- inputs and projections of the medial prefrontal cortex
- inputs and projections of the dorsolateral prefrontal cortex

Any help and websites links would be truly appreciated.



Dark Lord of the Sith
Moderator Emeritus
15+ Year Member
Jun 4, 2001
Attending Physician
The prefrontal cortex has many inputs and outputs. In fact, it is one of the most well-connected parts of the brain, positioned to coordinate information from and exert control over a variety of regions.

I like to think of the connections in two big groups:
1) intracortical (i.e. association projections to other cortical regions)
2) cortical-subcortical (i.e. thalamocortical, corticothalamic, cortico-striatal, corticobulbar, corticospinal, cortico-limbic, etc).

The main thalamic nucleus projecting to and receiving input from the prefrontal cortex is the mediodorsal nucleus. Different subdivisions of the MD nucleus project to different regions of the prefrontal cortex.

In addition, various neuromodulatory systems project to the prefrontal cortex and release neurotransmitters like dopamine, norepinephrine, seratonin, and acetylcholine.

There are also direct projections from PFC to the hypothalamus and midbrain periaqueductal gray.

There are various review articles out there you can use for more of the specifics.

Good luck.
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