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prefrontal cortex

Discussion in 'Neurology' started by lazure, Apr 21, 2004.

  1. lazure

    lazure Senior Member
    7+ Year Member

    Jan 15, 2004
    Likes Received:
    Hi guys,
    I'm the process of writing up an essay on biology of aggression in children/adolescents. I need two specific bits of information:

    - inputs and projections of the medial prefrontal cortex
    - inputs and projections of the dorsolateral prefrontal cortex

    Any help and websites links would be truly appreciated.

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  3. chizhikai

    chizhikai New Member

    Dec 17, 2003
    Likes Received:
    #2 chizhikai, Apr 21, 2004
    Last edited: Jun 24, 2008
  4. Vader

    Vader Dark Lord of the Sith
    Moderator Emeritus 10+ Year Member

    Jun 4, 2001
    Likes Received:
    Attending Physician
    The prefrontal cortex has many inputs and outputs. In fact, it is one of the most well-connected parts of the brain, positioned to coordinate information from and exert control over a variety of regions.

    I like to think of the connections in two big groups:
    1) intracortical (i.e. association projections to other cortical regions)
    2) cortical-subcortical (i.e. thalamocortical, corticothalamic, cortico-striatal, corticobulbar, corticospinal, cortico-limbic, etc).

    The main thalamic nucleus projecting to and receiving input from the prefrontal cortex is the mediodorsal nucleus. Different subdivisions of the MD nucleus project to different regions of the prefrontal cortex.

    In addition, various neuromodulatory systems project to the prefrontal cortex and release neurotransmitters like dopamine, norepinephrine, seratonin, and acetylcholine.

    There are also direct projections from PFC to the hypothalamus and midbrain periaqueductal gray.

    There are various review articles out there you can use for more of the specifics.

    Good luck.

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