protection of alcohol? what do they mean

[estradiol9]

The MCAT organic chemistry topic list includes "protection of alcohols" under the list of important reactions. What reactions are they referring to?

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[bananaz]

When you're conducting a reaction with a compound that has an -OH group that would interfere with the desired outcome (during Grignard reactions, for example), you need to first add a compound called a protecting group that will essentially "deactivate" the hydroxy group. Then after the reaction you can add a deprotecting group to turn it back into an alcohol.

You might find this helpful: http://mcat-review.org/alcohols.php

 

[NuttyEngDude]

weird, I didnt learn this reaction, should i just learn it with Cl-SiMe3 or am I ok with using something like TBDMS. unfortunately just saying "protection of alcohols" is pretty vague.

 

[syoung]

supposed to be in your orgo 2 or 3 (semester/quarter)

 

[Jear]

It's usually taught along with hemiketals/ketals and hemiacetyls/acetyls. If those sound familiar, then you probably learned about protecting groups, and just don't remember them now.

 

[railgun]

The MCAT organic chemistry topic list includes "protection of alcohols" under the list of important reactions. What reactions are they referring to?

I believe they are referring to the protection of alcohol from those that come randomly into your parties

Idk how much detail you need to know about that

 

[Ronson]

your timing is impeccable. j co recently posted a video on protecting groups:

http://www.youtube.com/watch?v=GZ0R-qIClBg

 

[fas376]

your timing is impeccable. j co recently posted a video on protecting groups:

http://www.youtube.com/watch?v=GZ0R-qIClBg

What exactly is j co? I stumbled upon one of their videos last week. It wasn't too bad.

 

[Jear]

your timing is impeccable. j co recently posted a video on protecting groups:

http://www.youtube.com/watch?v=GZ0R-qIClBg

For those who were asking, J Co is a series of online animated lectures in the four MCAT sciences. It's new, but it's been gaining notoriety (at least among the people I've spoken with).