Quasi-important pharm missing from First Aid

[ScubaStarved]

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I searched but could not find a similar thread, so forgive me if this is a repost. I was thinking it might be handy (and even time-saving) if people were to compile a list of drugs (or indications for drugs) that FA omits. Grouped by level of certainty with which they might prove helpful. If you feel so inclined, feel free to flesh out the list with 1-2 lines max of indication, mechanism (if known), and ADEs.

Apologies in advance to the mods if this violates TOS.

"Highest probability" of appearing:
OPG-RANK system


A prominent question resource includes:
Reserpine - MA depletion from pre-synaptic terminal. Rx HTN w/ ADE of severe depression.
Sunscreens (PABA vs Avobenzone) - UVA vs UVB coverage.
Primidone --> phenobarbitol. For partial seizures?
Amifostine - free radical scavenger to decr toxicity of cisplatin.
Cidofivir - CMP for VZV in HIV+.
Raltegravir - integrase inhibitor.


Interesting drugs with lower probability of appearing:
Argatroban et al - direct thrombin inhibitors.
Rasburicase - for tumor lysis syndrome.
Methylnaltrexone - naltrexone with methyl. Cannot cross BBB.

 

[pottymouth]

What about the newer generation anti-Histamines that are non-drowsy, less anti-cholinergic side-effects?

 

[ScubaStarved]

What about the newer generation anti-Histamines that are non-drowsy, less anti-cholinergic side-effects?

FA2010 has a list of 2nd gen H1 blockers: fexofenadine, loratadine, desloratadine, and cetirizine. Explanation for decreased sedation is that they have decreased entry into the CNS.

One interesting tidbit is that serotonin blockade is responsible for increased hunger with the 1st gen H1 blockers. Also see: SSRIs induce weight loss (esp. in atypical depression), except in anorexia, for which they are considered first line therapy.