of course you should always ask questions regarding the school. You should have about 3 questions prepared before going into the interview. Sometimes questions pop up during the interview that you didn't think about before. These are the best questions because the interviewer then knows that you are engaging in a two-way conversation.
I heard the program assistant is very helpful and she happened to be my interviewer. So, I thought the best question to ask her was, "what type of problems or questions do you get from first year students and how do you go about helping them solve these problems?"
It's a legit question that I think most first year students want to know and it also puts the interviewer in a hot seat so you can take a breather for yourself.