-
Practice your interview with the new SDN AI Interview Coach. Choose a school, answer by voice or typing, and receive a personalized feedback report. Available now to all SDN members. Try the AI Interview Coach.
Rad Onc Meme Thread
Started by evilbooyaa
Advertisement - Members don't see this ad
Read today's Quadshot
Quadshot:
The primary outcome of clinician-graded acute grade 2+ mucositis was significantly lower with proton therapy (7.4% v 22.7%). Grade 2+ dysgeusia was also lower with proton therapy (9.3% v 31.8%). However, there were no significant differences in patient-reported adverse effects.
Manuscript:
Although randomized, the trial was not blinded.
Quadshot:
The primary outcome of clinician-graded acute grade 2+ mucositis was significantly lower with proton therapy (7.4% v 22.7%). Grade 2+ dysgeusia was also lower with proton therapy (9.3% v 31.8%). However, there were no significant differences in patient-reported adverse effects.
Manuscript:
Although randomized, the trial was not blinded.
Brilliant. Did Vince Gilligan rip off Chris Nolan a little? I always thought so.
Patients, who have no financial incentive whatsoever: no statistically significant difference in PROs.
Unblinded physicians practicing in a system with every incentive to justify a very expensive, highly reimbursed technology: IT WORKS!
Unblinded physicians practicing in a system with every incentive to justify a very expensive, highly reimbursed technology: IT WORKS!
Sort of makes you question the clinical judgement and ethics of the authors on the study
On the other hand if it’s unblinded (so not placebo controlled drug trials) patients can also report Lower tox if they think it should be lower because they’re getting something they perceive to be ‘better’
Evergreen
"It is difficult to get a man to understand something, when his salary depends on his not understanding it." -Upton Sinclair
H&N RT has come a long way when the field is attempting to reduce Grade 2 acute mucositis.
An interesting tidbit (at least to me):
FUNDING: This study was funded by the Memorial Sloan Kettering Cancer Center Department of Radiation Oncology Research and Development funds.
A three site randomized IIT of 98 patients with 3 year follow up ain't cheap.
Evicore or CMS, take your pick.
Advertisement - Members don't see this ad
Really remarkable how much rad onc has lost over the last thirty years … 6 weeks of breast for everyone, 8-9 weeks of prostate for low to high risk, adjuvant lung, GI, two weeks of palliative RT, whole brain and now PCI. When does a grain of sand being added to itself over and over become a pile or a heap.
Good thing we are training more than ever!
May I add:
- rectal cancer (we are out in MSI-high and some patients only get 5 fractions)
- esophageal cancer (most are now ADC and ESOPEC made us irrelevant there) & gastric cancer
- pancreatic cancer (failed trials over and over again)
- hodgkin's lymphoma / DLBCL (deferred regularly in good responders on PET)
Most of the "gains" we are making are oligometastatic/-progressive disease, re-irradiation and countless courses of palliative RT for the stage IV patients that seem to live longer and longer due to the drugs they are getting.
I would count external beam APBI as a gain, as it reintroduced us into over-70 breast cancer s/p lumpectomy. I also wouldn't downplay SBRT for oligomets as much. It's been a pretty decent part of my practice, and it's pretty satisfying to play such an impactful role in Stage IV disease when used appropriately.
Arthritis also counts, as does the increased interest in benign conditions. Sure, it should always have been a part of the playbook, but I'm glad it's finally getting the respect it deserves.
I still treat a lot of rectal cancer, and I would argue the recent data pushes back against 5-fraction rectal enough that it's finally more or less dead in routine cases.
I also still treat a decent amount of pancreatic cancer, so I can't agree it's completely dead. Our role has always been somewhat nebulous and hard to define here. Hopefully systemic advances get to the point where local control again makes a difference.
Finally, I don't think the esophageal story is over. I can, before the end of my career, see us getting to a TNT rectal-style esophageal protocol. I have a hard time believing the data wouldn't support it.
Arthritis also counts, as does the increased interest in benign conditions. Sure, it should always have been a part of the playbook, but I'm glad it's finally getting the respect it deserves.
I still treat a lot of rectal cancer, and I would argue the recent data pushes back against 5-fraction rectal enough that it's finally more or less dead in routine cases.
I also still treat a decent amount of pancreatic cancer, so I can't agree it's completely dead. Our role has always been somewhat nebulous and hard to define here. Hopefully systemic advances get to the point where local control again makes a difference.
Finally, I don't think the esophageal story is over. I can, before the end of my career, see us getting to a TNT rectal-style esophageal protocol. I have a hard time believing the data wouldn't support it.
'Most of the "gains" we are making are oligometastatic/-progressive disease, re-irradiation and countless courses of palliative RT for the stage IV patients that seem to live longer and longer due to the drugs they are getting.'
this should not be understated. for those of us with busy practices - this is why.
this should not be understated. for those of us with busy practices - this is why.
its all about the gainz, bruh
For PCI, whole brain, 5-6 weeks breast, good riddance.
Derm anesthesia GI aren’t that innovative but are still good specialties to practice.
Other than imrt and sbrt what other advances have their been in rad onc?
We do need innovation in order to stop losing indications. Imagine if med onc still only had platinum and anthracyclines.
There’s nothing wrong with lack of innovation, but it is dumb to pump out residents like an oil spigot in that environment. Lack of innovation plus overtraining is worst of all worlds.
Derm anesthesia GI aren’t that innovative but are still good specialties to practice.
Other than imrt and sbrt what other advances have their been in rad onc?
We do need innovation in order to stop losing indications. Imagine if med onc still only had platinum and anthracyclines.
There’s nothing wrong with lack of innovation, but it is dumb to pump out residents like an oil spigot in that environment. Lack of innovation plus overtraining is worst of all worlds.
We will probably lose early stage breast at some point to a biomarker.
At 5 fx I find that to be unlikely
Seems like a good poly market bet- what indication will xrt loose next?
Advertisement - Members don't see this ad
I'm simming a 64 yo in a couple hours for APBI. She said she wouldn't have done RT if I suggested more than that. I'm not afraid of losing Stage I ER+ breast tany time soon.
Problem is that is a significant part of most practices’ volume.
We may have quantum computers in the next 10 years and possibly AGI, but predicting the 1/10 early stage breast that will benefit from radiation is beyond human capacity?
Maybe it will be an ultra sensitive ctdna or a biomarker/genetic signature. I am sure there are a lot of academic radoncs working hard to eliminate xrt. Corey spears (?) was claiming that he came up with a biomarker test that was commercialized a few years ago. Going to be a lot of shots on goal
Maybe it will be an ultra sensitive ctdna or a biomarker/genetic signature. I am sure there are a lot of academic radoncs working hard to eliminate xrt. Corey spears (?) was claiming that he came up with a biomarker test that was commercialized a few years ago. Going to be a lot of shots on goal
Last edited:
It is kinda wild how evidence-based decision making goes completely out of the window when it comes to endocrine therapy in early-stage breast cancer patients.
