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I had read somewhere a while ago that radiation therapy induces cell death via free radical formation, not because of mutations caused to DNA.
Would the cells recognize the damage and apoptose, or do they undergo necrosis?
Could someone please explain + give a mechanism?
My follow-up question would be if this is similar to free radical formation secondary to re-perfusion injury, such as that associated with post-MI myocardium; this produces coagulative necrosis.
Is there a similarity between the former and latter?
Cheers,
Would the cells recognize the damage and apoptose, or do they undergo necrosis?
Could someone please explain + give a mechanism?
My follow-up question would be if this is similar to free radical formation secondary to re-perfusion injury, such as that associated with post-MI myocardium; this produces coagulative necrosis.
Is there a similarity between the former and latter?
Cheers,