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I ask these questions out of pure curiousity. If you have any insight, please chime in.
1) Lets say I took a young healthy 70 kg person and gave her a large bolus of normal saline with the intention of inducing fluid overload
a) How many liters would be required to induce clinical symptoms of heart failure?
b) How many liters would be requried to necessitate intubation?
2) Lets say I take the same person who, for the purpose of discussion, has known normal patent coronary arteries. I insert an arterial line and bleed off several liters of whole blood while replacing the lost volume with normal saline so that the person is normovolemic and normotensive but profoundly anemic. How low would the hemoglobin have to be for that person to...
a) have demand ischemia? (i've normally only seen demand ischemia with volume loss)
b) die?
c) Would someone with chronic anemia but no other medical conditions have a greater tolerance for profound anemia?
3) What percentage of zygotes (successfuly egg fertilizations)...
a) successfully implant into the placenta?
b) survive the first two weeks? (50% according to one source)
c) Yield live born children?
4) How many cases of traumatic brain injury result from combat sports (boxing, mixed martial arts, traditional martial arts), and what type of strike is most likely to yield serious injury? (a crushing hook, a knee, an elbow, a head kick, a body slam?)
5) Is it possible for repeated non-devastating blunt trauma to the testicles to cause male infertility? (non-devastating meaning not counting injuries that would avulse the testicles or require urgent surgery).
6) Are there examples of balanced polymorphisms other than sickle cell anemia (and other blood dyscrasias) where the carrier state yields a selective advantage?
7) For a young athletic person, what volume status maximizes athletic performance? It is good to be hypovolemic, euvolemic, or hypervolemic?
8) Which type of exercise program would be most beneficial in terms of maximizing lifespan?
Please try to provide evidence based sources if possible, but I am not opposed to the application of clinical experience alone. Please add random questions of your own to the thread.
1) Lets say I took a young healthy 70 kg person and gave her a large bolus of normal saline with the intention of inducing fluid overload
a) How many liters would be required to induce clinical symptoms of heart failure?
b) How many liters would be requried to necessitate intubation?
2) Lets say I take the same person who, for the purpose of discussion, has known normal patent coronary arteries. I insert an arterial line and bleed off several liters of whole blood while replacing the lost volume with normal saline so that the person is normovolemic and normotensive but profoundly anemic. How low would the hemoglobin have to be for that person to...
a) have demand ischemia? (i've normally only seen demand ischemia with volume loss)
b) die?
c) Would someone with chronic anemia but no other medical conditions have a greater tolerance for profound anemia?
3) What percentage of zygotes (successfuly egg fertilizations)...
a) successfully implant into the placenta?
b) survive the first two weeks? (50% according to one source)
c) Yield live born children?
4) How many cases of traumatic brain injury result from combat sports (boxing, mixed martial arts, traditional martial arts), and what type of strike is most likely to yield serious injury? (a crushing hook, a knee, an elbow, a head kick, a body slam?)
5) Is it possible for repeated non-devastating blunt trauma to the testicles to cause male infertility? (non-devastating meaning not counting injuries that would avulse the testicles or require urgent surgery).
6) Are there examples of balanced polymorphisms other than sickle cell anemia (and other blood dyscrasias) where the carrier state yields a selective advantage?
7) For a young athletic person, what volume status maximizes athletic performance? It is good to be hypovolemic, euvolemic, or hypervolemic?
8) Which type of exercise program would be most beneficial in terms of maximizing lifespan?
Please try to provide evidence based sources if possible, but I am not opposed to the application of clinical experience alone. Please add random questions of your own to the thread.
