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Hello everybody
I do not know if this question is asked in a right place, but I really do not know where I can seek help.
The problem is that when a pharmacist reconstitutes cyclophosphamide (using a closed-system transfer device - CSTD - Phaseal), insoluble particles appear in the syringe.
These particles are not an insoluble drug. They look like a kind of rubber stopper (from a vial). This situation only takes place during reconstitution of cyclophosphamid.
The drug manufacturer claims that the possible cause is the presence of ABS in a closed transfer system. However, the CSTD manufacturer claims that, of course, ABS is present in the system, but it has no contact with the drug.
Thus, my question is : Have you ever met or heard of similar situation?
If not, maybe could you advise me where can I look for a help ?
I do not know if this question is asked in a right place, but I really do not know where I can seek help.
The problem is that when a pharmacist reconstitutes cyclophosphamide (using a closed-system transfer device - CSTD - Phaseal), insoluble particles appear in the syringe.
These particles are not an insoluble drug. They look like a kind of rubber stopper (from a vial). This situation only takes place during reconstitution of cyclophosphamid.
The drug manufacturer claims that the possible cause is the presence of ABS in a closed transfer system. However, the CSTD manufacturer claims that, of course, ABS is present in the system, but it has no contact with the drug.
Thus, my question is : Have you ever met or heard of similar situation?
If not, maybe could you advise me where can I look for a help ?
