Regenerative Nodules in Cirrhosis (MRI)

[Dr.Mrads]

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What is the histological explanation for regenerative nodules being hypo in T2 and then becoming hyper intense on T2 when they degenerate into HCC?

 

[cowme]

RNs have a variable appearance.

Can be t1 bright from copper, or completely invisible.

The ones you do see as t2 hypointense contain iron are siderotic nodules (t2 hypointense due to t2* effects).

Hcc, as with most tumors, have more water content than background liver, hence the t2 hyper intense signal. Hcc displaces iron in siderotic nodules, hence the conversion from T2 hypo to hyper

 

[Dr.Mrads]

Nice. Thank you.