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elephantfoot

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Currently I am a freshman doing research at my state schools attached med school, but I feel like the opportunities for me to make any contribution are very little. I spent most of the year collecting data by, running QPCR's and doing some mouse takedowns and sectioning, but don't really get to do anything else. I ask questions about the research and try to have some discussion about it, but none of the mentors seem to want to really talk to me about the projects, they just ask me to collect data and I don't get to participate in any intellectual discussion. Lots of times, my mentors are not in the lab and when I ask what I should/can be doing they just say there's nothing to do and I end up sitting around in the lab for hours. Sometimes when I ask to try/watch new experiments, I am told they are too complicated and cant do them. Additionally, my PI doesn't really want to let me do anything like westerns or antibody staining because the antibodies cost money. I have asked about the possibility of taking on a independent project due to the amount of downtime I have just sitting around in the lab and my PI has said yes, but I'm kind of getting the runaround when I try to take it further. I have done wet lab research for private companies before but never in a university setting, so I am not sure if this is the norm for the undergrad experience in a academic lab. I am just not sure if I should continue to stay in this lab or try to find a different one.
 
Currently I am a freshman doing research at my state schools attached med school, but I feel like the opportunities for me to make any contribution are very little. I spent most of the year collecting data by, running QPCR's and doing some mouse takedowns and sectioning, but don't really get to do anything else. I ask questions about the research and try to have some discussion about it, but none of the mentors seem to want to really talk to me about the projects, they just ask me to collect data and I don't get to participate in any intellectual discussion. Lots of times, my mentors are not in the lab and when I ask what I should/can be doing they just say there's nothing to do and I end up sitting around in the lab for hours. Sometimes when I ask to try/watch new experiments, I am told they are too complicated and cant do them. Additionally, my PI doesn't really want to let me do anything like westerns or antibody staining because the antibodies cost money. I have asked about the possibility of taking on a independent project due to the amount of downtime I have just sitting around in the lab and my PI has said yes, but I'm kind of getting the runaround when I try to take it further. I have done wet lab research for private companies before but never in a university setting, so I am not sure if this is the norm for the undergrad experience in a academic lab. I am just not sure if I should continue to stay in this lab or try to find a different one.

I'm reminded of "wax on, wax off,"

karate kid GIF


If this is your first time ever in an academic research lab, you should focus on perfecting the techniques you are charged with learning. Focus on data collection, analysis, and presentation. If you don't get this down, you won't be able to hang in more substantive discussions. Your duties are based on your mastery of physiology to date, and you will get your chance with an independent project with a graduating thesis.

For now, you have to show you aren't wasting money by screwing up western blots and immunohistochemistry. Make the most beautiful tissue sections and stains that the lab has ever seen. Show us you can be trusted. Damn straight, you and other newbie freshmen cost the lab money, and in the world of extremely limited funding, it is the PI's right to manage their lab budgets. Labs in "industry" don't have the same financial pressures, but your project can change on a whim outside the supervisor's control.

Did you make it clear what techniques you mastered in the private company? Are the techniques and tools in this lab similar? Are you able to show your technical precision to your lab peers?

The most important thing you can do is to stay on the "right side" of your PI by showing your value and mastery in the lab. Don't get over your skis too much... you are a freshman, and you don't want to burn bridges too early.

For an imperfect analogy: I wouldn't want someone fresh out of bootcamp to fly an F-15.
 
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No offense, but what do you think research is? Collecting data (running QPCRs and mouse takedowns and sectioning) IS research.

Again, no offense, but if you're a college freshman, do you have the background to engage in intellectual discussion?

I have done wet lab research for private companies before but never in a university setting
Legitimate question: you're at most 19 if you're a freshman. How much research experience could you reasonably have?

Sometimes when I ask to try/watch new experiments, I am told they are too complicated and cant do them. Additionally, my PI doesn't really want to let me do anything like westerns or antibody staining because the antibodies cost money.
Yes? That's absolutely true. Usually I wouldn't let a student do techniques like that until they'd been in the lab for a long time and showed me that they were patient, that they were willing to do the common work that is the backbone of research collection, and often not until they'd advanced enough in their coursework that they both knew the theory behind the complex techniques they wanted to use AND had done those techniques in a teaching lab.
 
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Yes? That's absolutely true. Usually I wouldn't let a student do techniques like that until they'd been in the lab for a long time and showed me that they were patient, that they were willing to do the common work that is the backbone of research collection, and often not until they'd advanced enough in their coursework that they both knew the theory behind the complex techniques they wanted to use AND had done those techniques in a teaching lab.
I see, I just wanted some confirmation that this is the normal undergrad research experience.
 
Did you make it clear what techniques you mastered in the private company? Are the techniques and tools in this lab similar? Are you able to show your technical precision to your lab peers?
Right now everything I do is the same in technique to what I did before in the private company(QPCR, rna extraction, etc.), the only new things I have learned were sectioning and some cell culture stuff. I'm required to present data every week and my PI says everything looks good(Good QPCR replicates, clean sections(not allowed to do stains yet due to cost), etc).
 
I'm going to take a hard left from the advice offered, fair warning.

I can agree and understand that, as a freshman, you generally do not yet have the wherewithal to be able to participate in these elaborate doctoral-level discussions in the lab. However, that comparison is not entirely fair.

Your PI went to graduate school to study their little hyperspecific slice of science, and all of their grad students are building their careers on that same tiny slice. That slice may be covered reasonably well by a basic science curriculum, but it may not be. It is probably more likely not to be.

The reason why it matters is because the same reasoning can be used to exclude you from any conversations/experiments in the lab, basically in perpetuity. It is unreasonable for a PI to ever expect you to go toe-to-toe with one of their PhD students, and they know that. I worry that you're wasting your time, and I think if you plan to continue moving forward in this lab, you need to ask pretty direct, uncomfortable questions of the PI. I think you have to sit down and agree on milestones.

Why? You are not rewarded for doing endless grunt work in medical school admissions. If you have crazy mega hours from freshman year and you never get to publish or present anything, you're going to get looked at sideways in admissions. If your PI is dismissive now, what do you think your LOR is going to look like later on?

To be fair and more balanced, I think you're doing a lot for a freshman. Most students are just doing chores: washing dishes, autoclaving stuff, performing inventory, helping to proofread manuscripts for grammar. So it's not totally hopeless: the PI is clearly allowing you to actually participate in the scientific process.

I sound the alarm primarily to wake you up to the fact that closed mouths don't get fed. If you do not know what to ask for, and you don't take the initiative to learn and ask, you can very well spend 3 or more years working tirelessly under a PI that "had no idea" you were working toward a specific goal they "never imagined" you would need for your application. On their end, they were satisfied to have the extra set of hands that cost them nothing and that ask nothing of them.

Keep your eyes open.
 
I sound the alarm primarily to wake you up to the fact that closed mouths don't get fed. If you do not know what to ask for, and you don't take the initiative to learn and ask, you can very well spend 3 or more years working tirelessly under a PI that "had no idea" you were working toward a specific goal they "never imagined" you would need for your application. On their end, they were satisfied to have the extra set of hands that cost them nothing and that ask nothing of them.
While this is absolutely true, I see more students take this as "annoy the crap out of the PI because they don't want to do the basic research that everyone has to do and constantly want to do more / do something cooler".

While this isn't everyone, it's about 50% of the pre-med research students that I give a shot in my lab. They don't have the patience to do basic science, they don't take the time to really understand the techniques we're doing or why we do them, but they constantly ask to do more complicated experiments that they don't have the background for and that aren't particularly relevant to anything other than their view of their future CV.

Most of them end up not being offered a chance to return to the lab, and get at best a lackluster LOR for me. But you know who gets great LORs? The students that understand that research involves a lot of tedium, a lot of doing the same thing over and over, and are willing to put in the time to do those things. And do them well. They almost always get invited to become more and more involved after they've shown that they're willing to do what all of the rest of us have to do, in addition to the cool things.

Why? You are not rewarded for doing endless grunt work in medical school admissions. If you have crazy mega hours from freshman year and you never get to publish or present anything, you're going to get looked at sideways in admissions.
This is, at least in my experience, very much not true. Anyone on an admissions committee knows that sometimes research is slow. If someone's working on a longitudinal animal model project, they might well not be on a publication. But if they display a strong understanding of the work and they have a strong letter discussing their work ethic, willingness to contribute to the project, and a combination of independence and teamwork? That's going to be a lot better than being 5th author on a bunch of token publications or having written some meta analyses that no one is going to read. Anyone who's been in the field for long enough can tell when a student was actually involved in the research vs. was just there at the right time and got a name on something, and the latter really isn't that valuable.
 
While this is absolutely true, I see more students take this as "annoy the crap out of the PI because they don't want to do the basic research that everyone has to do and constantly want to do more / do something cooler".

While this isn't everyone, it's about 50% of the pre-med research students that I give a shot in my lab. They don't have the patience to do basic science, they don't take the time to really understand the techniques we're doing or why we do them, but they constantly ask to do more complicated experiments that they don't have the background for and that aren't particularly relevant to anything other than their view of their future CV.

Most of them end up not being offered a chance to return to the lab, and get at best a lackluster LOR for me. But you know who gets great LORs? The students that understand that research involves a lot of tedium, a lot of doing the same thing over and over, and are willing to put in the time to do those things. And do them well. They almost always get invited to become more and more involved after they've shown that they're willing to do what all of the rest of us have to do, in addition to the cool things.

I'm sure there are people like that. But consider what the OP says:

"I ask questions about the research and try to have some discussion about it, but none of the mentors seem to want to really talk to me about the projects, they just ask me to collect data and I don't get to participate in any intellectual discussion. Lots of times, my mentors are not in the lab and when I ask what I should/can be doing they just say there's nothing to do and I end up sitting around in the lab for hours. Sometimes when I ask to try/watch new experiments, I am told they are too complicated and can't do them."

To me, that doesn't sound like someone who is not interested in the basic science. It sounds like someone who is begging to be mentored, which is pretty much the PI's only true responsibility to the student. Some students carry in their own grants and have previous experience, serving their labor to the PI on a silver platter, and they are still treated like toddlers drawing on the walls with markers.

I don't think it's fair to expect that a student be infinitely enthusiastic for years on end as their very limited runway for traditional admissions elapses while they are spinning on an office chair in the lab, relegated to minimal involvement. We both know that would not be an appropriate relationship with an undergraduate student, and such an arrangement heavily favors the PI's convenience over what is consistently presented in academia as a learning experience for the student. The labor is supposed to be a coincidental perk, not the organizing center of the experience, at least, that's what medical schools appear to try to convince us of.

If it is annoying the crap out of a PI to have a conversation about common sense milestones and establishing some ground rules so the terms of engagement are mutually beneficial, that is a very unfortunate situation given that it is literally the mentor's job to take initiative on that point and not dump responsibility for self-advocacy onto the student. In such a case it would be not only highly improper as an administrator managing labor, but also incredibly unprofessional as a mentor to expect a student to be satisfied with chronic cursory dismissal.

And then, to add insult to injury, sprinkle in a black mark on the LOR so that future opportunities are dashed with plausible deniability, even if you'll have 10 other students go through the lab in the next year or two and you won't remember this particular student with any fidelity by the time they try to use the letter.

Or no? You tell me.

This is, at least in my experience, very much not true. Anyone on an admissions committee knows that sometimes research is slow. If someone's working on a longitudinal animal model project, they might well not be on a publication. But if they display a strong understanding of the work and they have a strong letter discussing their work ethic, willingness to contribute to the project, and a combination of independence and teamwork? That's going to be a lot better than being 5th author on a bunch of token publications or having written some meta analyses that no one is going to read. Anyone who's been in the field for long enough can tell when a student was actually involved in the research vs. was just there at the right time and got a name on something, and the latter really isn't that valuable.

I agree with the spirit of your comment. Research should be evaluated that way. From what I can tell about the residency and medical school admissions games, though, it appears nobody on the adcom has the time to undergo that kind of rigorous evaluation on the merits of any particular applicant's research. It seems an awful lot like all they care about is that it was published in a C/N/S journal and that there are a lot of them. Surely such accomplishments do not make "better" dermatologists, orthopods and neurosurgeons, but it is what is rewarded.

I am obviously not there yet but I take it that the recent changes to ERAS in the vein of consolidating scholarly contributions aims to shift the culture in that respect, though, how effective that will actually be on the student side is yet to be seen.

In general, my perception is that most physician hopefuls don't want to do research and wouldn't do so if it were not a quasi-requirement of the admissions machine. At the end of the day, it's just a completely different job. In both pre-med and medical school, the clock is ticking. Pre-meds don't want to take gap years, and medical students do not want to take research years. Both are perceived as failures, rightly or wrongly.

In that way, I think students are just reacting to the rules presented to them. They are trying to min-max on a finite resource. And, ultimately, the PI is not the only individual in their lives that insists they take the #1 priority. Every single professor/authority for every single class/activity believes they are the most important, essential conduit of information and experience for the student, and each takes on a particularly haughty attitude when confronted with the reality that the student is often balancing totally incompatible demands (including their own) pretty much by default. Nobody seems to acknowledge the irony, but everyone is very willing to poo-poo on the student for being "totally neurotic and CV crazy."

I could go on, but this has already gotten pretty long.
 
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I feel like you're putting a spin on things that is likely personal and unlikely to lead to productive future discussions. It does seem a little bit like you have a chip on your shoulder related to past experiences with PIs, and perhaps don't also have experience from that side of the mentor/mentee relationship. I appreciate you taking the time to share your thoughts, but I don't think we're likely to make any positive ground by continuing further.
 
I feel like you're putting a spin on things that is likely personal and unlikely to lead to productive future discussions. It does seem a little bit like you have a chip on your shoulder related to past experiences with PIs, and perhaps don't also have experience from that side of the mentor/mentee relationship. I appreciate you taking the time to share your thoughts, but I don't think we're likely to make any positive ground by continuing further.

I disagree, but I acknowledge and respect your reticence to engage on the merits. In fact, this interaction very much undergirds my entire point: when a student attempts to negotiate boundaries and they are refused due to the massive power imbalance between authorities and students, they are framed as the problem and discarded.

Certainly, being direct accelerates this outcome, but I think most students would rather know if their "mentor" plans on punishing them with impunity now and not years down the line.

See how that works, OP?