The MOA in FA for rifampin is a bit confusing. It says that it is a DNA dependent RNA polymerase inhibitor but then in the diagram for antivirals, rifampin is shown as blocking packaging and assembly of vaccinia. Does it do two things?
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Step I Rifampin MOA
Started by lemonade90
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Yeah. The assembly of vaccinia is reversibly blocked by rifampin. I remember reading/hearing somewhere that mutant vaccinia strains, demonstrating rifampin-resistance, have D13L mutations.
He was probably on the golf course, read a paper about D13L while he was waiting for his mate to tee off, and then crushed it 350 yds. Hate guys like this 😀
