Robbins basic pathology error?

[eur]

---

Members don't see this ad.

Hi, just wondering if this is a mistake or not in Robbins basic pathology 7th ed. On page 47 of the acute and chronic inflammation chapter, in the paragraph summing up the plasma proteases functions, it says on bullet point 1: "(3) the fibrinolytic system, producing plasmin and degrading thrombin" Doesn't plasmin break up fibrin? And also in the same page/paragraph on bullet point 4: "Thrombin has significant side effects on multiple cells and pathways(leukocyte adhesion, vascular permeability, and chemotaxis)." Isnt it supposed to be C5a and not thrombin?

Thanks

 

[Droopy Snoopy]

Hi, just wondering if this is a mistake or not in Robbins basic pathology 7th ed. On page 47 of the acute and chronic inflammation chapter, in the paragraph summing up the plasma proteases functions, it says on bullet point 1: "(3) the fibrinolytic system, producing plasmin and degrading thrombin" Doesn't plasmin break up fibrin? And also in the same page/paragraph on bullet point 4: "Thrombin has significant side effects on multiple cells and pathways(leukocyte adhesion, vascular permeability, and chemotaxis)." Isnt it supposed to be C5a and not thrombin?

Thanks

Big Robbins? p.47 is the Chapter 2 outline. You are correct though that plasmin breaks up fibrin clots.

 

[Gut Shot]

"(3) the fibrinolytic system, producing plasmin and degrading thrombin" Doesn't plasmin break up fibrin?

Yes, it breaks up fibrin, which is the sort of what the fibrinolytic system does.

"Thrombin has significant side effects on multiple cells and pathways(leukocyte adhesion, vascular permeability, and chemotaxis)." Isnt it supposed to be C5a and not thrombin?

Perhaps, but even if it's an error, thrombin really gets around.

 

[coolmamajama]

Yep, thrombin is both pro- AND anti-thrombotic, depending on what the problem is at the moment.

As for your second question, you're right about C5a (and C3a), but thrombin does have effects on leukocyte adhesion, vasopermeability and chemotaxis as well.