I know that both H+ and CO2 compete with O2 for the binding spot on Hb.
Using the blood buffer equation:
H2O + CO2 -> H2CO3 -> HCO3- + H+
So I came across a concept/question that stated: Increasing HCO3- would get rid of H+ and increase affinity of Hb for O2. But wouldn't that also contribute to an increase in CO2 which decreases the affinity of Hb for O2? I am confused as to why they are not taking he affects of CO2 into consideration.
How should I approach this questions? I immediately thought of the blood buffer equation and thought that more HCO3- would result in more CO2 being produced which would decrease affinity of Hb for O2. What am I doing wrong?
How would an increase in bicarbonate (HCO_3^-HCO3−) relative to all other molecules in the blood affect the oxygen affinity of hemoglobin and why?
Please choose from one of the following options.
Using the blood buffer equation:
H2O + CO2 -> H2CO3 -> HCO3- + H+
So I came across a concept/question that stated: Increasing HCO3- would get rid of H+ and increase affinity of Hb for O2. But wouldn't that also contribute to an increase in CO2 which decreases the affinity of Hb for O2? I am confused as to why they are not taking he affects of CO2 into consideration.
How should I approach this questions? I immediately thought of the blood buffer equation and thought that more HCO3- would result in more CO2 being produced which would decrease affinity of Hb for O2. What am I doing wrong?
How would an increase in bicarbonate (HCO_3^-HCO3−) relative to all other molecules in the blood affect the oxygen affinity of hemoglobin and why?
Please choose from one of the following options.
- Decrease oxygen affinity by directly binding with hemoglobin
- Increase oxygen affinity by binding with free protons
- Decrease oxygen affinity by binding with free protons
- Increase oxygen affinity by directly binding with hemoglobin