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substrate concentration and affinity question

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danielsgirl0403

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As a general question in kinetics, when we are under LOW conditions of substrate, do we want HIGH or LOW affinity for the substrate?

I have in my notes that when we are under low substrate conditions, we want low affinity for the substrate because we don't want to be using it up so much since we are low? Not sure where I got this from, but my logic may be wrong because it just sounds weird to me. This also is sort of a reference to B/B sample Test #23 question.
 
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