A lot to unpack here but a few thoughts and anecdotes that you all can take or leave.
As most have said, the idea for paralytics before sedative hypnotic is literally just trying to align the onset time. With that said, I typically donāt do this because itās just as easy to swing the other way (as youāve alluded) and provide weakness/air hunger/terror to your pt prior to anesthesia. Now in a true life/death scenario I guess the risk/reward is still in favor of saving them at the expense of a few seconds of discomfort. But I typically just use propofol flushed with sux. In controlled inductions when I have either precurarized or given a defasciculation dose itās not entirely rare for you to see patients eyes go wide or them to note a noticeable weakness/onset of difficulty breathing. And thatās with 5 or 10mg of Roc literally seconds before induction dose of sedative. In elective or semi elective inductions I think itās cruel. For this reason I just use Roc for my elective or controlled non-emergent inductions (which is in large part because sugammadex is so available to me these days). In your typically crashing life saving scenario? Iād use sux if no contraindications as itās just faster, though 1.2mg/kg of Roc isnāt all that much slower.
Considering ED drug and nursing logistics I understand your guys issues. But Iāve seen many many pts brought in by EMS or post intubation in the trauma bay hypertensive/tearing etc because they got 10-20mg of etomidate with 50-100mg of Roc 30 minutes ago. I donāt know how to fix that aside from a decent slug of versed or system based reform to protocolize benzo or your amnestic/sedative of choice to show up with your RSI kits. You could also have Neo added to the same protocol. Yes, this is a naive anesthesiologist thinking I could change ED culture or entrenched rules but I will tell you, no group of anesthesiologists would let that fly if the hospital or pharmacy tried to enact restrictions like that on us. In particular I think no push dose pressor readily available at inductions is a non starter.
Regarding weak paralytic dosing? This makes zero sense to me. If the airway is scary the decision isnāt light relaxant itās sleep or no sleep. If you give enough sedative to get to intubation youāve already walked out onto the bridge of apnea or at least suboptimal ventilation, giving a partial dose of paralytic probably extends your time to secured airway due to suboptimal views. Then you hit a point where you either give more paralytic to improve your look but then hypnotic is wearing off. I just see that as a wandering cluster of suboptimized conditions.
Last anecdote Iāll mention is regarding ketamine. I think, at least in my hands, in adults, itās a garbage induction agent. I completely understand the idea and why you guys like it, it maintains spontaneous ventilation (usually) and it likely provides much longer effective sedation and pain control for your patients you have to scan or line up etc post secured airway and paralysis. I get it and Iām not trying to convince any of you to change your practice. What I will say, is it isnāt always the perfect respiratory drive preserving drug without hemodynamic compromise. In patients that are tapped out and living on their sympathetics, you will see significant hemodynamic collapse. When I was fresh out of training I used to try to do tamponade inductions by the book; maintain negative pressure ventilation, maintain sympathetic outflow, avoid hemodynamically depressant drugs etc. So, urgent/emergent pericardial windows Iād try to induce with Ketamine, DL/ETT, light PPV to see ventilatory impact on pulse pressure etc. You know what? Ketamine or maybe just an un-relaxed/non-paralyzed DL sucks. It just does. You then give more Ketamine. Then they donāt have the SNS molecules to throw at you and they tank anyways. So now, Iām a wiser less concerned with what the book may say type guy and the question still boils down to sleep or not to sleep. If theyāre that sick, they canāt lie back, canāt speak in full sentences, they look terrified, etc? Sorry, you get an awake local anesthetic assisted percutaneous drain. Then we go to sleep. If you look stable-ish or I think I can secure the airway without an impending crash? Prop/sux or roc/push dose pressor, tube.
You guys have a hard job, you guys need to fight the pharmacy and clipboard warriors and get the tools you need. Not having push dose meds or sedatives readily available would drive me nuts.