Serum osteopontin test?

[EUA]

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There's been a couple articles linking elevated serum osteopontin levels with asbestos-related pleural mesothelioma. Is anyone familiar with any commercial labs that offer this test for clinical use, or is it used solely in research?

 

[pathman2006]

The FDA has no formal approvals for it for commercial use that I could see on their site. Quest does not offer it.

Here is something from CDC with a link at the end--hope this helps

While very promising, the panelists agreed that blood tests for mesothelin and osteopontin “are not ready for primetime.” There are currently many unanswered questions about how the detected levels correlate with the development of mesothelioma, specifically there is an unacceptable level of false positives and false negatives. Further, this technique may not be useful for screening asbestos exposure in communities with low-level environmental exposures. Additional research should be conducted to improve the sensitivity and specificity of the technique.


http://www.atsdr.cdc.gov/asbestos/a... Asbestos Meeting Summary_9-19-06-2_final.pdf

 

[pathman2006]

The FDA has no formal approvals for it for commercial use that I could see on their site. Quest does not offer it.

Here is something from CDC with a link at the end--hope this helps

While very promising, the panelists agreed that blood tests for mesothelin and osteopontin “are not ready for primetime.” There are currently many unanswered questions about how the detected levels correlate with the development of mesothelioma, specifically there is an unacceptable level of false positives and false negatives. Further, this technique may not be useful for screening asbestos exposure in communities with low-level environmental exposures. Additional research should be conducted to improve the sensitivity and specificity of the technique.


http://www.atsdr.cdc.gov/asbestos/a... Asbestos Meeting Summary_9-19-06-2_final.pdf

 

[kchan99]

I have heard of research into serum osteopontin as a marker for ovarian cancer. Here is the link to the abstract of a recent paper.