You really should do a search before posting because I've answered this question a couple times.
As a DO, you can't get around the COMLEX. Some DO schools may even require you to pass Steps 1 & 2 in order to graduate.
Your profile states that you're pre-med, so it's a little early to be worried about taking the COMLEX or USMLE. I had the same question, so I called all of the programs I was interested in. None of them required the USMLE.
Personally, I think taking the USMLE has more chances of hurting you. It only benefits you if you can score as well as or better than the COMLEX. I know you can choose which scores to submit, but isn't it better when your have good scores to show?
Any way, I graduated from NSUCOM in 2003. If you have any questions regarding DOs & pathology, feel free to ask.
----- Antony