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- May 15, 2016
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I've been trying to figure out exactly what enzyme or receptor spironolactone inhibits. I saw somewhere that it inhibits 11Beta-hydroxylase but then wouldn't that lead to decreased cortisol also or is there something more selective going on? Also, at 11B-hydroxylase, haven't you already synthesized 11-deoxycorticosterone which still has aldosterone properties?
#clueless
#clueless