steroids

[workhardplayhar]

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How do they cause hypocalcemia and hypokalemia?

 

[Miami_med]

How do they cause hypocalcemia and hypokalemia?

I'm pretty sure that there is some cross reactivity with aldosterone receptors, which causes the hypokalemia. The hypocalcemia, I don't know.

 

[Taus]

Besides the cross reactivity w/ aldost recepters, there is also some weak aldosterone activity in some of the adrenal cortex synthetic pathways and the breakdown products of corticosterone (ie why you can have hypertension in congenital adrenal hyperplasias w/o having aldosterone). So now its just thinking about what aldosterone is doing. Simply put, its bringing back Na and peeing out K and H. So far you have hypokalemia and metabolic alkalosis. The alkalotic conditions pull off H+ from the COOH on albumin's amino acids. Albumin now has an excess of COO(-) which binds free Ca2+.....and now you have hypocalcemia...tetany...etc

 

[Mezz]

Besides the cross reactivity w/ aldost recepters, there is also some weak aldosterone activity in some of the adrenal cortex synthetic pathways and the breakdown products of corticosterone (ie why you can have hypertension in congenital adrenal hyperplasias w/o having aldosterone). So now its just thinking about what aldosterone is doing. Simply put, its bringing back Na and peeing out K and H. So far you have hypokalemia and metabolic alkalosis. The alkalotic conditions pull off H+ from the COOH on albumin's amino acids. Albumin now has an excess of COO(-) which binds free Ca2+.....and now you have hypocalcemia...tetany...etc

this individual seems incredible intelligent ^