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Studies on Quetiapine?
Started by FuturaDocta
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This is a very broad question since there are plenty of studies on this medication, and the definition of "stellar" is going to vary depending on the person.
My own opinion of the medication is not high since it scored the lowest on the CATIE trial (which is a stellar study in almost any psychiatrist's opinion), and its side effect profile with weight gain, sedation & hyperlipidemia was not good either. IMHO its weak med with strong metabolic side effects.
However there is a time & place for every medication, even quietapine, which needs to be determined by the specific doctor who is supposed to factor in the specific medication, and how it will affect the invidual in question.
My own opinion of the medication is not high since it scored the lowest on the CATIE trial (which is a stellar study in almost any psychiatrist's opinion), and its side effect profile with weight gain, sedation & hyperlipidemia was not good either. IMHO its weak med with strong metabolic side effects.
However there is a time & place for every medication, even quietapine, which needs to be determined by the specific doctor who is supposed to factor in the specific medication, and how it will affect the invidual in question.
I too agree that it is very broad. But, thanks for your answer.
If you don't mind me asking, since you sound familiar with the drug, is there a chance that the drug would not work at all on some patients? What if the sedation does not seem to take affect at all? On some previous studies, there should be signs of improvement within a 6 weeks or so. However, if this is not the case, what other medication do you personally think is better?
(I know I should NOT seek medical advice on the internet. But, I just want your opinion. That's all. And, thanks for the quick responses🙂)
If you don't mind me asking, since you sound familiar with the drug, is there a chance that the drug would not work at all on some patients? What if the sedation does not seem to take affect at all? On some previous studies, there should be signs of improvement within a 6 weeks or so. However, if this is not the case, what other medication do you personally think is better?
(I know I should NOT seek medical advice on the internet. But, I just want your opinion. That's all. And, thanks for the quick responses🙂)
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I believe I can answer this since I'm not answering it specific to an individual, and in generalities (moderators correct me if I'm wrong).
All meds, despite their typical presentations can have better, worse or atypical presentations depending on the individual. E.g. Zyprexa which causes tremendous weight gain in several patients, even more so than quietapine, in several does not.
Here is an algorithm for antipsychotics...
http://www.medscape.com/content/2003/00/45/89/458907/458907_fig.html
If you want to get more specific than that, I suggest you read up on the CATIE trial. It has very specific side effects for each atypical antipsychotic minus Abilify.
http://content.nejm.org/cgi/content/abstract/353/12/1209
More specific than that, a doctor needs to incorporate the pros & cons of every medication available to treat the disorder, and factor in the patient's own profile (age, sex, weight, medical problems, health status, lifestyle, symptom profile, etc) vs the benefits & risks of each medication. E.g. quietapine in the CATIE trial cause the most amount of QT prolongation, Clozaril, Zyprexa & Seroquel caused the most amount of weight gain & increase in lipid profile, Risperdal caused the most amount of prolactin increase....yada yada yada.
From the above paragraph on--it really has to be determined by the treating doctor. I can only speak in generalities, the treating doctor has to judge for his/her individual patient.
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Thanks. That's all I really need!
I just noticed the alrgorithm is a bit older than I thought & did not mention Abilify, Invega or Geodon. Both (edit--all 3) are atypicals and should be considered in the same category as Risperdal, Zyprexa & Seroquel.
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You mentioned weight gain a couple of times. In the past studies, it shows that about 40% of the participants experienced weight gain. I was just wondering how much weight gain should be expected. Would you consider this to be one of the indicators if someone is taking their meds?
I would. Again, this needs to be done by the individual doctor. For several patients there is no way to know if they will gain weight until it happens.
However, I will say a good doctor will notice weight gain on the order of 5-10 lbs quickly after medication has started and will discuss the issue, and give options to continue it or switch to another medication before it balloons to 100 lbs of weight gain. That is something I have not seen every doctor do.
However, I will say a good doctor will notice weight gain on the order of 5-10 lbs quickly after medication has started and will discuss the issue, and give options to continue it or switch to another medication before it balloons to 100 lbs of weight gain. That is something I have not seen every doctor do.
Wow! 100 lbs.... I don't know what would be considered more of a risk factor in health. I just read the article. It is greatly informative. Thank you.
