Stupid last minute question about Fructose

[username456789]

Page 104 at the bottom of the first section mentions high levels of blood fructose causing osmotic damage due to its alcohol building up. I was under the impression that the whole reason essential fructosuria is benign is because it's not an aldose and doesn't do any aldose reductase reactions (it comes into the cell, realizes there are no enzymes for it to play with, so it takes its ball and goes home back to the blood).

Lazy oversight by FA? Or some other reaction I don't know about?

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[MilkmanAl]

Probably a lazy oversight since fructose can also be shunted through glycolysis via hexokinase when it's present in high concentrations.

 

[username456789]

Probably a lazy oversight since fructose can also be shunted through glycolysis via hexokinase when it's present in high concentrations.

UW has taught you well (that's one of the things I definitely didn't realize until coming across that UW question).

Thanks.