DrRoyal Pains

7+ Year Member
Jul 29, 2010
839
9
Philadelphia
Status
Dental Student
Hey guys, I have a stupid question to ask, but I just want to make sure I am right. A carboxyl group on a benzene ring is deactivating because of the partial + charge on the carbon as a result of being bonded to oxygen, right?
 
Jul 6, 2011
23
0
Status
Pre-Dental
Yes- the polar C-O bond can withdraw electron density (inductive effect). Also, electrons can resonate up into the carboxyl group which removes electron density as well. The inductive and resonance effects reinforce each other... this deactivates the ring.
 
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