USMLE Thrombosis and Endothelial Cell Damage

[justadream]

According to Pathoma, one of the causes of thrombosis is endothelial cell damage.

This is because endothelial cells normally prevent thrombosis (via several mechanisms - too many to list here).

However, one of the acute phase reactants (acute phase reactants are secreted when there is inflammation - and I would think endothelial cell damage would qualify as causing inflammation?) that is upregulated is fibrinogen (which causes coagulation).

So it seems like endothelial cell damage causes thrombosis (which is bad). But the fibrinogen secreted as a acute-phase reactant would actually worsen the situation?

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