transport vesicles Q.

[Jaba]

---

Members don't see this ad.

Science Question:

This quetion deals with the V-SNAREs that are used in transport vesicles from trans Golgi to the plasma membrane. These proteins are integrated into the membrane of the ER during translation and then are transported by COPII vesicles to the cis-Golgi. The COPII vesicles contain more than 2 v-SNAREs including:
1. those targeting COPII vesicles to the cis-Golgi membrane
2. those in transit for targeting trans-Golgi-derived secretory vesicles to the plasma membrane.

my question is why might this mechanism be a problem, and what possibilities might the cell do to resolve this problem. If anyone uses Lodish et al 5th Molecular Cell Biology maybe you could direct me to the important page? I am very confused about this. Any other help is appreciated.

Thanks

 

[americanpierg]

3 pi

 

[captaintripps]

Science Question:

This quetion deals with the V-SNAREs that are used in transport vesicles from trans Golgi to the plasma membrane. These proteins are integrated into the membrane of the ER during translation and then are transported by COPII vesicles to the cis-Golgi. The COPII vesicles contain more than 2 v-SNAREs including:
1. those targeting COPII vesicles to the cis-Golgi membrane
2. those in transit for targeting trans-Golgi-derived secretory vesicles to the plasma membrane.

my question is why might this mechanism be a problem, and what possibilities might the cell do to resolve this problem. If anyone uses Lodish et al 5th Molecular Cell Biology maybe you could direct me to the important page? I am very confused about this. Any other help is appreciated.

Thanks

What exactly is your question, I'd like to help, but am confused about what you're asking for.

 

[howui3]

Science Question:

This quetion deals with the V-SNAREs that are used in transport vesicles from trans Golgi to the plasma membrane. These proteins are integrated into the membrane of the ER during translation and then are transported by COPII vesicles to the cis-Golgi. The COPII vesicles contain more than 2 v-SNAREs including:
1. those targeting COPII vesicles to the cis-Golgi membrane
2. those in transit for targeting trans-Golgi-derived secretory vesicles to the plasma membrane.

my question is why might this mechanism be a problem, and what possibilities might the cell do to resolve this problem. If anyone uses Lodish et al 5th Molecular Cell Biology maybe you could direct me to the important page? I am very confused about this. Any other help is appreciated.

Thanks

sounds like you are in Cell Bio class. The DAT will not ask anything this detailed or vague.

The obvious problem is once the vesicle goes to the golgi and then to plasma membrane how are the V-SNAREs - on the vesicle membrane )there are also T-SNARES - on the target membrane) return to ER.

Is this what you are looking for?

very vague question, problem with fusion, production, return of snare molecules?

check the INDEX of the book, it will tell you the page where the COPI and COPII are discussed.

 

[Joz]

Science Question:

This quetion deals with the V-SNAREs that are used in transport vesicles from trans Golgi to the plasma membrane. These proteins are integrated into the membrane of the ER during translation and then are transported by COPII vesicles to the cis-Golgi. The COPII vesicles contain more than 2 v-SNAREs including:
1. those targeting COPII vesicles to the cis-Golgi membrane
2. those in transit for targeting trans-Golgi-derived secretory vesicles to the plasma membrane.

my question is why might this mechanism be a problem, and what possibilities might the cell do to resolve this problem. If anyone uses Lodish et al 5th Molecular Cell Biology maybe you could direct me to the important page? I am very confused about this. Any other help is appreciated.

Thanks

A mutation in the genes coding for either of the V-SNARE proteins (pre and post Golgi targetting) could lead to a loss of function, resulting in the inability of COPII vesicles to adequately target the Golgi for modification or the inability of secretory vesicles to target the plasma membrane for secretion. This could either result in complete loss of secretory pathway, or just a diminished quantity of the secreted product successfully exiting the cell.

The cell doesn't really posess a remedy for a problem such as this that I know of. I'm sure there are many other problems that are associated with secretion, but as far as V-SNARES go, I'd say that mutations would be pretty devastating.