metairie's an option if you stay on Lake Avenue, i lived there for a semester ... that's the border of jefferson parish and orleans parish, and there are nice apartments there and it's a 6 mile drive to campus. 20 min in traffic, 12-15 without traffic. there's so much darn construction that even coming from uptown takes close to 15 minutes.
i live in the fountainbleu neighborhood, just north of uptown and next to midcity, it's 2.5 miles from school, 1.5 miles to the Reilly center and pretty safe.
but hawaiin is right, uptown is probably the best bet. lots of options, decently close to school, close to Reilly, and not too pricey unless you're on the undergrad campus, then they hike up the rent a bit, but it's still reasonable.