Coming from a "prestigious school with a rep. for grade inflation," I can tell you that it just isn't true. Years ago, that was the case at some universities, mostly because students could drop a class the day of the final without it showing on their transcript, and also take a class over and over again without the repeat showing on the transcript. So, obviously that helps to get higher grades -- it's not that the professors themselves graded the students easier b/c of the school they were at. These policies have all been reversed, and most AdComs are aware of that. That being said, I do think AdComs take your undergrad institution into account, but the MCAT score should be a great equilizer. I know, it seems unfair -- I felt the same way when applying to undergrad from a public high school. I have to say that at least at my college, the vast majority of public school kids were ranked 1 or 2 in their H.S. classes, and had >1400 SATs, while the private school kids had generally lower stats. However, I soon had to admit that a lot of these private school kids did just as well, and often outperformed the public school kids, b/c their high schools had provided them with more challenging work. It's not totally fair, but as long as you keep your GPA and MCAT numbers up, no matter where you are, you should be fine. Also, I think you have to realize that the applications process in general is an unfair, arbitrary business. There's really no use in getting bitter about it.