I just finished the SS program with a post-bac GPA of just below 4.0, and am applying this year.. so I'll be sure to let you guys know my experiences.
To address some of the things in this thread:
1) Dr. Hollander's class.. for Clinical Research in EM... it's basically a class where you got to put the work and effort into. When I say work and effort, I mean taking the initiative to get along with people, talk to people, and do your job... it's more of a job than a class. Ergo, it's more political than anything. Show up on time, do your job well, don't shirk your responsibilities and you'll be fine. Exams are a complete crock and is the only negative thing about the class. Great way to get clinical exposure.
2) Grace leaving: well, while she's given me some pretty good information on who to talk to at certain medical schools (I have some specific personal details that are relevant to medical schools), I don't mind either way. She already wrote my committee letter. I'm sorry to see her go, but a lot of the direction in this program was self-directed. I read up as much as I could on SDN and from friends, so I more or less knew what I needed to do. So, in a way, I just wanted her to write my committee letter and that would be that. So I'm not that upset about her leaving.
3) SS classes: As a SS student, the classes are not difficult at all compared to the classes I took in undergrad. Maybe 90% of the classes I took were not curved. For instance, Molecular Bio and Genetics, Vertebrate Physiology, Immunology, etc. are not curved. That being said, you still have to bust your chops to make the cut, since it's not that easy to attain a 93+ average in some of these classes. Think of it this way: conceptually easy, but you have to pay your dues. The last 10% of the classes were curved but again, you gotta pay your dues and hope for the best. Worked out for me.
4) Pre-health classes: They can be quite hard, because these are pretty much like undergrad where it's curved around C+/B-, and the cutoffs are not known in advance. You'll need to bust your chops, especially if you are in the Pre-Health program and taking Bio, Chem and Physics with all 3 labs in one semester like a few people did.
5) Community: to be honest, it's a bit segregated. Pre-health people are actually pretty tight with each other, since its a 2+ year program. Since I was taking a few PH classes, I didn't fare too badly. On the other hand, SS people tend to be more reclusive in a way. Either way, you'll meet new people, some fresh out of college, and some older people. Again, its what you make of it - if you want to make friends, go out and make friends! If you just want to study, then by all means...
6) BBB classes: they'll count as Biology, because it's an 'off-shoot' of the Biology department. Even Clinical Research in EM counts as Biology on my verified transcript. So, believe it when they tell you it does. (I was initally skeptical, but hey, my verified AMCAS application is living proof).
7) Letters of recommendation/committee letter process: They do a pretty solid job here, but the first day we can get our letters sent out is August 1st.. no matter how early Grace finishes it. It's something that Penn Career Services does, not CGS, so it's not the post-bac's fault here. But my letter has been finished since late June and I'm not even allowed to send in a request. Quite irritating.
8) Research opportunities: University City teems with opportunities to find research work. You've got HUP/Penn Med, CHOP, Jefferson, Temple, as well as the Sciences building on Market St... you can find something to your heart's desire. You just gotta go out and look hard. Again, it's a political thing - learn to work people.
Any more questions, just post here and I'll try to respond.