Vaccine poll

[Chartreuse Wombat]

Let's take a poll.
No I don't intend to publish in RJ

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[scarbrtj]

Don't think vaccines are hard, it's the target here (no vaccine for common cold, or HIV, ...); but I get your point. Recently had an explanation by a smart med student as to why she thought a COVID virus wouldn't be found due its particular class/(molecular) genetic structure. Don't remember, so can't repeat, but she made sense at the time.

 

[Chartreuse Wombat]

Don't think vaccines are hard, it's the target here (no vaccine for common cold, or HIV, ...); but I get your point. Recently had an explanation by a smart med student as to why she thought a COVID virus wouldn't be found due its particular class/(molecular) genetic structure. Don't remember, so can't repeat, but she made sense at the time.

Yes the nature of the virus and lack of previous success with coronaviruses is what motivated the answer

 

[Mandelin Rain]

Yes the nature of the virus and lack of previous success with coronaviruses is what motivated the answer

Agreed with this. I find it unlikely that there will be a safe, effective, and lasting immunity via vaccine.

 

[KHE88]

Hot off the presses...

https://www.nejm.org/doi/full/10.1056/NEJMoa2022483

 

[Chartreuse Wombat]

Hot off the presses...

https://www.nejm.org/doi/full/10.1056/NEJMoa2022483

Encouraging but a long way to go.

 

[Ray D. Ayshun]

Lasting immunity? Isn't once or twice a year good enough? When you weigh yearly to semiyearly vaccines against the course of the common cold it doesn't seem worth making a vaccine. The present situation is different.

 

[Mandelin Rain]

That study out of China showed neutralizing immunity disappearing within 8 weeks in as many as 40% of people, worst if not symptomatic.

 

[KHE88]

That study out of China showed neutralizing immunity disappearing within 8 weeks in as many as 40% of people, worst if not symptomatic.

Any evidence that points to a solution that doesn't involve forcing republicans to wear masks under penalty of law and public shaming, I'm not really interested in hearing about. That's basically what this has boiled down to.

 

[Ray D. Ayshun]

That study out of China showed neutralizing immunity disappearing within 8 weeks in as many as 40% of people, worst if not symptomatic.

6 shots a year then? I bet with a radonc running the fda we'll be able to get it down to 3 bigger shots a year with equivalent cosmesis...

 

[scarbrtj]

When/if vaccine developed, theoretically all humans should get it? And if so, all humans contain a subset of humans getting radiation.
So... hold radiation or no for the COVID vaccine

 

[deleted605854]

My guess is that it'll be a multiple shot vaccine per year and not that effective. Healthcare professionals will probably have to maintain adequate antibody titers. For civilians I've no idea. Maybe only in the winter or something?

Or maybe there won't be one and there will be a new normal

 

[thecarbonionangle]

The chances of a vaccine are low. We have never succeeded in making one against corona viruses is my understanding. i know of people who had the virus and had “negative” abs (the test often doesn’t give you a titer quantification but a thumbs up or down)

 

[medgator]

The chances of a vaccine are low. We have never succeeded in making one against corona viruses is my understanding. i know of people who had the virus and had “negative” abs (the test often doesn’t give you a titer quantification but a thumbs up or down)

In another blow to ‘herd immunity,’ study shows decline of COVID-19 antibodies after a few weeks

A study published on July 11 by researchers at King’s College London found that antibodies detected in the human body which fight the coronavirus declined after just a few weeks, leaving the possibility of herd immunity out of the question.

www.fox13news.com

 

[Lamount]

We don't need a vaccine to make 100% of recipients immune. When it does work, we don't need it to last forever. All the vaccine needs to do is get the R0 under 1... then this goes from a chain reaction to a smoldering fire.

 

[Pointless]

About the argument of never having a vaccine for coronaviruses... have we ever had a coronavirus that caused enough trouble to warrant this level of attention? Kind of a rhetorical question because the answer is no. We have every developed nation along with most every large pharma company exhausting all efforts to produce a workable vaccine, something that I can safely say has never occurred previously to vanquish the mighty common cold.

Data from the Moderna phase I in NEJM seems to suggest the booster dose is what results in the more robust response and so the hope is that a two-shot vaccine schedule will produce a more lasting immune response. I remain hopeful that we will have a vaccine by early 2021.

 

[RickyScott]

Apparently T cell response which is tough to measure as opposed to neutralizing antibodies is key here.