- Joined
- Apr 5, 2016
- Messages
- 95
- Reaction score
- 48
For example when you face obstacles?
yes, it is just a general question.Is this a general question or are you trying to find a reason of your on? Shouldn't it be the end result of reaching your goal?
Can you give me a reference on this one?I just cured someone's 20 year history of constipation that has failed *everything*, with vitamin D supplementation!!!!
such a simple, almost obvious basic wellness intervention that no one had thought to suggest before, and it's made a *huge* impact on their *daily* quality of life!
How do you wish to change it?Coming from a disadvantaged background, the dream to change the field medicine, knowing this is my life calling, the fact that I am fortunate enough to chase my purpose, choosing to believe life is beautiful, and knowing I will be the first doctor in my family.
I've found that it's helpful to "diversify" your motivation. For example, my motivation at any given point in time jumps between:For example when you face obstacles?
I can't wait for this one. It's terrifying to consider the possibility that school/training might take so many years that I'll be too late though. If only I could borrow money from my future attending self and help out my dad now, and then live like a resident for an extra 5-10 years. The time-travel-loan interest rate would be 0% too, which would be pretty nice haha. Ever worry about that type of thing?- The dream that I will have the means to take care of my parents and advocate for them as they continue to age.
Idk what your scholastic background is, but there are so many ways to pay for school that doesn't involve loads/debt.I can't wait for this one. It's terrifying to consider the possibility that school/training might take so many years that I'll be too late though. If only I could borrow money from my future attending self and help out my dad now, and then live like a resident for an extra 5-10 years. The time-travel-loan interest rate would be 0% too, which would be pretty nice haha. Ever worry about that type of thing?
Ways to pay potentially up to $80k/year for 4 years of med school? Do tell!Idk what your scholastic background is, but there are so many ways to pay for school that doesn't involve loads/debt.
It's a lot more of a headache at first, but it's amazing to be one of the few graduating without that hanging over you
Thanks, looking forward to the list! Maybe I'll just spend my whole senior year applying for those grants haha. Oops, my badWell scholarships are need or meri based, but grants, either from the government or from private businesses, are easier to get (from my experience)
And some pay for things like rent or books or school supplies,
And some pay a chunk of money periodically,
It's all dependent on that grant.
Honestly, it's time consuming at first, finding and applying, but they add up quickly, and it's money you never pay back.
So it's definitely worth it. I'll make a list of where to look for non-scam grants and how to resources and post it in the thread
Can you give me a reference on this one?
A reference would be a study (preferably an RCT) indicating that Vitamin D is superior to placebo in the treatment of intractable constipation.off the cuff I can explain the pathophys that I was addressing here, and you tell me if it's in line with what you learned in medical school, and if not let me know and I'll try to find a good source (I read this somewhere and filed the fact away, not the source as it typical for me)
one of the side effects of calcium supplementation is constipation
part of the rationale of including vitamin D in these supplements is not only that it increases calcium absorption, but in doing so you will also decrease the incidence of this side effect, essentially, calcium supplements shouldn't be given without vitamin D unless there's some other contraindication for D
basically, if the calcium remains unabsorbed in the gut, it can cause constipation
if you can encourage the gut to absorb it, you can decrease that side effect
anyway, this patient had lots of dairy in their diet
lactose intolerant patients will of course complain about diarrhea, this patient was not lactose intolerant
I read somewhere that the calcium in dairy is to blame for constipation due to dairy (only milk has D added, and some would argue it's not enough but in any case the rest doesn't)
patient wasn't taking vitamins, had an otherwise poor diet, and spent all their time indoors, it was reasonable to assume they had a vitamin D deficiency, or even if they would test normal, that vitamin D supplementation in a 50 year old sedentary woman with poor diet aside from hefty dairy intake wasn't a bad plan
they weren't hypothyroid
I had them increase water intake, increase dietary fiber, and use psyllium, and PEG, and docusate, all with no success (they didn't tolerate senna 2/2 bowel cramping pain) they were only pooping 1x per week and had so much nausea it was affecting their ability to eat. I ensured they were getting enough water with the fiber that the increase in fiber was not the culprit.
within 1 week of starting 2000 IU vitamin D daily (we continued water, good dietary sources of fiber & docusate, all of which had not been effective on their own but were tolerated unlike the psyllium and PEG), and they were pooping almost daily and felt loads better
I am crediting the addition of vitamin D and not increased water intake/dietary fiber/docusate because on their own that had failed, and it wasn't until vitamin D was added that the patient had benefit
this shoudn't seem shocking to you guys, do I really need to cite a source that one that unabsorbed calcium in the gut/ca supplements causes constipation?
http://www.doctoroz.com/episode/vitamin-americans-aren-t-getting-enoughA reference would be a study (preferably an RCT) indicating that Vitamin D is superior to placebo in the treatment of intractable constipation.
I knew better than to click on that.
I just want to be able to put extra guac on my chipotle without having to contemplate the additional charge.
Give me $400,000 a year and I'm good fam. Ballin' out at chipotle is a must.
A reference would be a study (preferably an RCT) indicating that Vitamin D is superior to placebo in the treatment of intractable constipation.
What you describe is not a case report.I ended up doing some research and couldn't find anything!
Not sure where I read or got that "pearl" to add vitamin D to decrease constipation one might suspect is due to calcium in dairy.
I didn't include that this patient had also been on promotility agents like Remeron (which the GIs are moving away from more and more) and failed.
No IBD red flags. Is due for a colonoscopy but this issue predates that.
I just got off another thread last night from EBM purists. And it comes up that quality large gold standard RCTs are often difficult to find when it comes to nutrition for a number of reasons. Someone made the case that one level of evidence is going to be what is biologically plausible/theoretical. Yes, as you point out, some things are attributable to placebo and I cannot rule out placebo effect without an RCT.
Anyway, I didn't mention that I actually lived with this person 24/7 during this time, and I know their med history quite well (have reviewed all records) and so I was able to observe compliance. In any case, they are more the type to have a nocebo effects and for "nothing to help" them. They were frankly shocked.
It's possible that bowel movments going from 1x weekly to every other day with only the addition of vitamin D in a patient who did not expect benefit is placebo, in my opinion the physiology I explained makes more sense to me but as you point out we would really need a study to determine it.
I'm not claiming the results here are hugely generalizable to the gen pop, but seeing as vitamin D was already indicated for this patient according to USPTF guidelines....
I don't really see the utility in arguing this particular case. I could write it up as a case study and just leave it at that. I'm sorry the evidence doesn't exist or if you either don't believe things as I have documented them. If you're just skeptical because it's an n=1 and case study evidence, I can certainly understand that.
I did have a chance to review some treatment algorithms for chronic constipation, and I would still argue in the vitamin D deficient patient where vitamin D is otherwise indicated anyway, there's no harm to trying vitamin D prior to initiating promotility agents which can have significant side effects.
Given what I know of this case, I believe that the supplementation made the difference, which is why I mentioned it in my original post.
YMMV.
What you describe is not a case report.