I took it with Ochem 2, Embryology, and Immunology first semester of senior year. Coming from a Molecular Bio major, I found biochem to be much easier than most of the other science courses. Immunology put Biochem to shame in terms of time invested, but I'm sure it depends on the teacher. It's not bad at all if you have down the basics from Ochem and a pretty thorough understanding of Molecular Bio. Somewhere on youtube is a video called "learn 20 amino acids in 20 minutes." Watch that a few times, know your arrow pushing mechanisms, and have your memorization skills dialed down and you should be good for an A. The intricacies can be a little intense but again, nothing more than an upper level MCDB course, and certainly a joke compared to 1st year med school classes. Biochem lab is another story though... that was a fair challenge.