I was in your exact same situation. First two years..grades weren't that great...I am talking D's, retakes, etc. However, the last years of college..all A's. The person who interviewed me actually said "Wow..there is definately a story here. Someday, I would like to know what it is." He was generally impressed with my 'turnaround'. However, I prepared for the worst! I shadowed as many docs as possible, got my EMT license, began respiratory therapy training, got a part time job in a hospital doing EKG's, sat in on any surgery I had time for..including orthopedic, baby delivery, gyno stuff, and even an AUTOPSY! I documented ALL OF THIS! When it came time to submit the secondary.........I attached this documentation to it, with Dr.'s names, dates, procedures, etc. I had a full page of medical exposure (besides my job and things I saw at the hospital all the time). This is what really impressed the adcom.
I admitted during my interview that I knew I had to do all of those things to make up for my first few years of college. Long story short...I got in to my first choice-KCOM.
Oh, and my MCAT was two days after I had my appendix removed..the scores weren't the best. So....if in doubt..study study study..and get that experience! It really does help. Good luck.