why singulair at night?

[badxmojo]

why is singulair reccomended to be taken at night time?
thanks guys!

---

Members don't see this ad.

 

[MNnaloxone]

From what I remember (don't trust this-it is way too early, and I'm in Cardiology today)-it was recommended at night because that is the way the efficacy studies were performed. Since the study patients got the drug at night-it was approved for dosing at night.

So why did Merck set up the trials for nightly dosing? A guess, but since asthma exacerbations supposedly occur more frequently at night or during exercise, it would make sense to target the disease when it is most prevalent with drug levels as high as possible.

 

[vafcarrot]

Is one of the side effects drowsiness? Maybe docs don't want you driving around after you've taken it.

 

[jacobtp]

why is singulair reccomended to be taken at night time?
thanks guys!

I looked in the product monograph and it states:

"The safety and efficacy of SINGULAIR? (montelukast sodium) was demonstrated in clinical trials where it was administered in the evening without regard to the time of food ingestion. There have been no clinical trials evaluating the relative efficacy of morning versus evening dosing. However, no difference in pharmacokinetics was noted between morning and evening dosing."

So I assume that means they only say to take it that way because that's what they THINK might be best, because that's how the testing was done. As in, when they tested the drug, they had the patients all take it in the evening.

 

[bananaface]

I looked in the product monograph and it states:

"The safety and efficacy of SINGULAIR? (montelukast sodium) was demonstrated in clinical trials where it was administered in the evening without regard to the time of food ingestion. There have been no clinical trials evaluating the relative efficacy of morning versus evening dosing. However, no difference in pharmacokinetics was noted between morning and evening dosing."

So I assume that means they only say to take it that way because that's what they THINK might be best, because that's how the testing was done. As in, when they tested the drug, they had the patients all take it in the evening.

There are 2 indications for Singulair: asthma and allergic rhinitis. In trials for allregic rhinitis, both morning and evening dosing regimens were evaluated, with no difference in efficacy. For treatment of asthma asthma the trials were performed at night only. The above quote is out of context and refers only to the trials for treatment of asthma. (per page 4 of prescribing information, under "General")

 

[jacobtp]

There are 2 indications for Singulair: asthma and allergic rhinitis. In trials for allregic rhinitis, both morning and evening dosing regimens were evaluated, with no difference in efficacy. For treatment of asthma asthma the trials were performed at night only. The above quote is out of context and refers only to the trials for treatment of asthma. (per page 4 of prescribing information, under "General")

Sorry about my mistake. I looked at an older one dated 08/25/2003. Your link shows a print date of April 2004. And the newer one details more of the 2 indications.

 

[UCFGrad]

Perhaps a little off-topic, but I have severe sinus nighttime allergies and I'd tried Claritin and Singulair, neither of which seemed to be effective. Don't know what was causing it, but for months I couldn't breath through my nasal passages when lying in a horizontal position. The only thing that did work was oxymetazoline HCl (Afrin). Had to use just a bit longer than as directed, but now I don't use it and the problem is no longer relevant.

 

[DeanH]

Also remember the onset is 3 - 4 hours. Why not be ready to go when you wake up as well as avoiding sleepness nights gasping for air

 

[ShadowRX]

Also remember the onset is 3 - 4 hours. Why not be ready to go when you wake up as well as avoiding sleepness nights gasping for air

Damn... what's with the zombie outbreak???

From '04, too?

 

[Sparda29]

Perhaps a little off-topic, but I have severe sinus nighttime allergies and I'd tried Claritin and Singulair, neither of which seemed to be effective. Don't know what was causing it, but for months I couldn't breath through my nasal passages when lying in a horizontal position. The only thing that did work was oxymetazoline HCl (Afrin). Had to use just a bit longer than as directed, but now I don't use it and the problem is no longer relevant.

Did you try Benadryl?

 

[pharm B]

Also remember the onset is 3 - 4 hours. Why not be ready to go when you wake up as well as avoiding sleepness nights gasping for air

Thanks. 🙄

 

[laimyours]

Pollen count is higher in the morning. If you take it in the morning it won't work for 3+ hours.

 

[samurai361]

Damn... what's with the zombie outbreak???

From '04, too?

lol..why not?

 

[ShadowRX]

You're right, my bad.

Just so... random, I guess. Singulair? In the middle of PharmCAS and PCAT questions? And I guess, another Bottlecap?

 

[samurai361]

You're right, my bad.

Just so... random, I guess. Singulair? In the middle of PharmCAS and PCAT questions? And I guess, another Bottlecap?

well I gave you a little more random hahaha. just wanted to push your buttons 😛

 

[deleted329060]

they come in stock bottles #30 so u usually just have to put a label on em and u are good 2go

random