why zona glomerulosa spared in secondary adrenal insuff?

[tarsuc]

Why is zona glomerulosa spared in secondary adrenal insufficiency. isnt acth responsible for the activation of Sidechain cleavage enzyme, and thus synthesis of aldosterone as well?

---

Members don't see this ad.

 

[gettheleadout]

Responsiveness of the zona glomerulosa to ACTH is very limited. A basal level of ACTH stimulation is required for constitutive expression of cholesterol desmolase, but mineralocorticoid production isn't altered in response to change in plasma ACTH levels.