why zona glomerulosa spared in secondary adrenal insuff?

[tarsuc]

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Why is zona glomerulosa spared in secondary adrenal insufficiency. isnt acth responsible for the activation of Sidechain cleavage enzyme, and thus synthesis of aldosterone as well?

 

[gettheleadout]

Responsiveness of the zona glomerulosa to ACTH is very limited. A basal level of ACTH stimulation is required for constitutive expression of cholesterol desmolase, but mineralocorticoid production isn't altered in response to change in plasma ACTH levels.